Amine‐Mediated Domino Reaction of Thioisatins: Synthesis of Benzothiophene‐fused N‐Heterocycles under Catalyst‐Free Conditions,Asian Journal of Organic Chemistry

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Amine‐Mediated Domino Reaction of Thioisatins: Synthesis of Benzothiophene‐fused N‐Heterocycles under Catalyst‐Free Conditions
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-12-07 , DOI: 10.1002/ajoc.202000626
Qingsong Deng ₁ , Aimin Yu ₁ , Meitong Li ₂ , Xiangtai Meng ₁

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A novel three‐component domino reaction between thioisatins, α‐bromoketones, and amines was developed. The reaction with aliphatic amines produced a series of benzothiophene fused pyrrolidones in good yields. Moreover, employment of diamines gave benzothiophene fused polycyclic compounds. In addition, gram‐scale experiments and synthetic transformations on the resulting products were performed.

中文翻译：

硫介素的胺介导的多米诺反应：在无催化剂条件下苯并噻吩稠合的N-杂环的合成

开发了一种新型的三组分巯基异黄素，α-溴代酮和胺之间的多米诺骨牌反应。与脂族胺的反应以良好的产率产生了一系列苯并噻吩稠合的吡咯烷酮。此外，使用二胺得到苯并噻吩稠合的多环化合物。另外，对所得产物进行了克级实验和合成转化。

更新日期：2021-02-10

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