Immune dysfunction contributes to the higher risk of communicable and non-communicable diseases among diabetics. HLA-DR expression is a robust marker of immune competence in mononuclear cells, including antigen presentation to CD4 lymphocytes. Given the high prevalence of obesity among diabetics, we evaluated the independent association between hyperglycemia and dyslipidemias with respect to HLA-DR expression in blood monocytes from type 2 diabetes patients. The monocytes from individuals with (n = 16) or without diabetes (n = 25) were phenotyped by flow cytometry to assess the differential expression of HLA-DR on their three subpopulations (classical, intermediate and non-classical monocytes). Diabetes was independently associated with lower HLA-DR expression across all monocyte subpopulations (p < 0.05). Blood triglycerides were associated with further HLA-DR depression (interaction p < 0.002). Cholesterols counterbalanced the reductive effect, with CD36, a receptor for oxidized cholesterol, correlating with HLA-DR (rho = 0.373; p = 0.016). Future studies are warranted to elucidate the complex interactions between hyperglycemia and dyslipidemias on antigen presentation in diabetic monocytes.

免疫功能障碍导致糖尿病患者患传染性和非传染性疾病的风险更高。HLA-DR 表达是单核细胞免疫能力的有力标志，包括向 CD4 淋巴细胞呈递抗原。鉴于糖尿病患者肥胖率较高，我们评估了高血糖和血脂异常与 2 型糖尿病患者血液单核细胞中 HLA-DR 表达的独立关联。通过流式细胞术对来自患有糖尿病 (n = 16) 或未患糖尿病 (n = 25) 的个体的单核细胞进行表型分析，以评估其三个亚群（经典、中间和非经典单核细胞）上 HLA-DR 的差异表达。糖尿病与所有单核细胞亚群的 HLA-DR 表达较低独立相关（p < 0.05）。血液甘油三酯与进一步的 HLA-DR 抑制相关（交互作用 p < 0.002）。胆固醇通过 CD36（一种氧化胆固醇受体）抵消还原作用，与 HLA-DR 相关（rho = 0.373；p = 0.016）。未来的研究有必要阐明高血糖和血脂异常之间对糖尿病单核细胞抗原呈递的复杂相互作用。