Non-alcoholic fatty liver disease (NAFLD) represents the leading cause of chronic liver disease worldwide and the anticipated health burden is huge. There are limited therapeutic approaches for NAFLD now. It’s imperative to get a better understanding of the disease pathogenesis if new treatments are to be discovered. As the hepatic manifestation of metabolic syndrome, this disease involves complex interactions between different organs and regulatory pathways. It’s increasingly clear that brain, gut and adipose tissue all contribute to NAFLD pathogenesis and development, in view of their roles in energy homeostasis. In the present review, we try to summarize currently available data regarding NAFLD pathogenesis and to lay a particular emphasis on the inter-organ crosstalk evidence.

中文翻译：

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多器官参与非酒精性脂肪肝的发病机制

非酒精性脂肪肝疾病（NAFLD）代表了全球慢性肝病的主要原因，预期的健康负担巨大。现在，NAFLD的治疗方法有限。如果要找到新的治疗方法，必须更好地了解疾病的发病机理。作为代谢综合征的肝脏表现，这种疾病涉及不同器官和调节途径之间的复杂相互作用。越来越清楚的是，鉴于脑，肠和脂肪组织在能量稳态中的作用，它们都对NAFLD的发病机理和发育做出了贡献。在本综述中，我们尝试总结有关NAFLD发病机理的当前可用数据，并特别强调器官间串扰证据。