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Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report
Journal of Ophthalmic Inflammation and Infection ( IF 2.9 ) Pub Date : 2020-12-07 , DOI: 10.1186/s12348-020-00226-y
Imen Ksiaa , Safa Ben Aoun , Sourour Zina , Dhouha Nefzi , Sana Khochtali , Moncef Khairallah

To describe a case of Behçet disease (BD) uveitis manifesting with sequential bilateral neuroretinitis associated with prepapillary inflammatory vitreous exudate (PIVE). A single case report documented with multimodal imaging. A 37-year-old man developed neuroretinitis with associated PIVE in the left eye. He was diagnosed with ocular toxoplasmosis and treated accordingly based on positive serologic testing and negative work-up for other entities, including BD. The disease course was favorable, but 1 year later a similar neuroretinitis developed in the right eye. Extraocular features of BD became evident only at the time of the second eye involvement, and the patient received corticosteroid and immunosuppressive therapy. Swept source (SS) OCT showed at the acute phase in both eyes a typical “mushroom-shaped” prepapillary hyperreflectivity of the PIVE. SS OCT angiography (OCTA) demonstrated a corresponding prepapillary hypointense area due to shadowing effect, decreasing in size while scanning deeper layers. It also detected peripapillary retinal hypervascularity in both eyes and a sectoral area of flow signal loss in the first involved left eye. Visual acuity improved following the resolution of the PIVE and associated acute inflammatory changes in both eyes. The left eye showed residual optic disc pallor and retinal nerve fiber layer defects. Sequential bilateral neuroretinitis associated with PIVE may occur before other clinical features of BD become evident. SS OCT and OCTA can provide useful information for the diagnosis and management of this rare, but typical, ocular manifestation of BD uveitis.

中文翻译:

序贯性双侧白塞氏神经性视网膜炎与乳头状前玻璃体渗出液相关:病例报告

描述一例Behçet病(BD)葡萄膜炎,表现为与乳头前炎性玻璃体渗出液(PIVE)相关的继发性双侧神经视网膜炎。用多模式成像记录的单个病例报告。一名37岁的男子在左眼发生了神经视网膜炎并伴有PIVE。他被诊断患有眼弓形虫病,并根据血清学检查阳性和其他疾病(包括BD)的阴性检查结果接受了相应治疗。病程良好,但一年后右眼出现了类似的神经视网膜炎。BD的眼外特征仅在第二眼受累时才变得明显,并且该患者接受了皮质类固醇和免疫抑制治疗。扫描源(SS)OCT在急性期在两只眼睛中都显示出PIVE的典型“蘑菇形”乳头前高反射率。SS OCT血管造影术(OCTA)由于阴影效应显示出相应的乳头前低点区,在扫描更深层时尺寸减小。它还在两只眼睛中检测到了乳头周围视网膜血管过度,在第一个受累的左眼中检测到了一部分流量信号丢失。PIVE消退后,两只眼睛的急性炎症改变,视力得到改善。左眼显示残余视盘苍白和视网膜神经纤维层缺损。在BD的其他临床特征变得明显之前,可能会发生与PIVE相关的顺序性双侧神经视网膜炎。SS OCT和OCTA可以为这种罕见的疾病的诊断和管理提供有用的信息,
更新日期:2020-12-07
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