Trend analysis, graphical representation, and summarization of pharmacological research trends were carried out to act as guidance for the future. The main objectives of the research are to find out the complete research trend on the national tree of India so far and to validate its traditional uses along with the pharmacological hepatoprotective activity of Ficus benghalensis L. by developing three in vitro experimental models. The fruit of the said plant (F. benghalensis) was extracted with different solvent (petrochemical ether, chloroform, ethyl acetate, ethanol, water) system and the yield value was determined. Phytochemical screening was also done with a different solvent. In an in-vitro study, the liver of freshly slaughtered goat (Capra Capra) was used for various investigational tests, and the hepatotoxicity was induced by carbon tetrachloride (CCl4) at a dose of 2 ml/kg, Acetaminophen at a dose of 7 g/kg, and with Erythromycin at a dose of 1.4 g/kg. The ethanol extract of fruits of F. benghalensis at the doses of 100 mg/kg, 250 mg/kg, and 500 mg/kg were used to observe its hepatoprotective effect against drug/chemical-induced in vitro hepatotoxicity as the model developed here with against a standard molecule, Silymarin. Amongst all solvents, ethanol was considered to be a universal solvent and resulted in a yield of 2.96%, which is maximum. Phytochemical screening of ethanol extract of fruit also showed the presence of alkaloids, steroids, flavonoids, carbohydrates, and glycosides. The protein concentration of liver homogenate based on comparison with standard protein concentration was found to be 1.6 mg/mL as measured at λmax of 750 nm. About the protein concentration, catalase (enzymatic) activity was also measured using the standard curve of H2O2, to calculate the specific activity of different models to compare the study results. The significant effect of the reduction of hepatotoxicity was found at a dose of 500 mg/kg of fruit extract against Silymarin. Evaluation of Hepatoprotective activity of fruit in terms of catalase activity with different models flourishing the new research scope to fulfill the shortage of availability of a new, efficient, safe hepatoprotective agent in upcoming days.

中文翻译：

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孟加拉榕榕的近期研究趋势（包括其体外保肝活性）的药理学审查和进展

进行了趋势分析，图形表示和药理研究趋势的概述，以作为未来的指导。该研究的主要目的是通过建立三种体外实验模型，找出迄今为止印度国家树的完整研究趋势，并验证其传统用途以及榕榕的药理保肝活性。用不同的溶剂（石化醚，氯仿，乙酸乙酯，乙醇，水）系统萃取该植物（F. benghalensis）的果实，并测定产量值。植物化学筛选也用不同的溶剂进行。在一项体外研究中，将新鲜宰杀的山羊（Capra Capra）的肝脏用于各种研究测试，肝毒性是由剂量为2 ml / kg的四氯化碳（CCl4），剂量为7 g / kg的对乙酰氨基酚和剂量为1.4 g / kg的红霉素诱导的。分别用100 mg / kg，250 mg / kg和500 mg / kg剂量的孟加拉镰刀果实的乙醇提取物观察其对药物/化学诱导的体外肝毒性的肝保护作用，因为这里建立的模型对抗标准分子水飞蓟素。在所有溶剂中，乙醇被认为是通用溶剂，其收率为2.96％，是最高的。水果乙醇提取物的植物化学筛选还显示出生物碱，类固醇，类黄酮，碳水化合物和糖苷的存在。与标准蛋白质浓度比较，发现肝脏匀浆的蛋白质浓度为1。在750 nm的λmax下测得6 mg / mL。关于蛋白质浓度，还使用过氧化氢的标准曲线测量过氧化氢酶（酶）的活性，以计算不同模型的比活性，以比较研究结果。在500 mg / kg的水果提取物对水飞蓟素的剂量下，发现降低肝毒性的显着效果。用过氧化氢酶活性评价水果的肝保护活性，采用不同的模型，这为新的研究范围提供了便利，以解决在未来几天缺乏新型，高效，安全的肝保护剂的需求。在500 mg / kg的水果提取物对水飞蓟素的剂量下，发现降低肝毒性的显着效果。用过氧化氢酶活性评估水果的肝保护活性具有不同的模型，这使新的研究范围蓬勃发展，以解决在未来几天内缺乏新型，高效，安全的肝保护剂的不足。在500 mg / kg的水果提取物对水飞蓟素的剂量下，发现降低肝毒性的显着效果。用过氧化氢酶活性评价水果的肝保护活性，采用不同的模型，这为新的研究范围提供了便利，以解决在未来几天缺乏新型，高效，安全的肝保护剂的需求。