Background Passive auditory oddball tests are effort independent assessments that evaluate auditory processing and are suitable for paediatric patient groups. Our goal was to develop a two-tone auditory oddball test protocol and use this clinical assessment in an immature large animal model. Event-related potentials captured middle latency P1, N1, and P2 responses in 4-week old (N = 16, female) piglets using a custom piglet 32- electrode array on 3 non-consecutive days. The effect of target tone frequency (250 Hz and 4000 Hz) on middle latency responses were tested in a subset of animals. Results Results show that infrequent target tone pulses elicit greater N1 amplitudes than frequent standard tone pulses. There was no effect of day. Electrodes covering the front of the head tend to elicit greater waveform responses. P2 amplitudes increased for higher frequency target tones (4000 Hz) than the regular 1000 Hz target tones (p < 0.05). Conclusions Two-tone auditory oddball tests produced consistent responses day-to-day. This clinical assessment was successful in the immature large animal model.

中文翻译：

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从被动双音听觉奇怪范式对健康 4 周龄仔猪进行目标检测

背景 被动听觉奇怪测试是一种独立于努力的评估，用于评估听觉处理，适合儿科患者群体。我们的目标是开发一种双音听觉奇怪测试方案，并在未成熟的大型动物模型中使用此临床评估。使用定制仔猪 32 电极阵列在非连续 3 天捕获 4 周龄（N = 16，雌性）仔猪的中潜伏期 P1、N1 和 P2 反应。在一组动物中测试了目标音调频率（250 Hz 和 4000 Hz）对中潜伏反应的影响。结果结果表明，不频繁的目标音调脉冲比频繁的标准音调脉冲引起更大的 N1 幅度。当天没有任何影响。覆盖头部前部的电极往往会引起更大的波形响应。对于更高频率的目标音调 (4000 Hz)，P2 幅度比常规 1000 Hz 目标音调增加 (p < 0.05)。结论 奇怪的双音听觉测试每天都会产生一致的反应。该临床评估在未成熟的大型动物模型中取得了成功。