Front Cover: Micaryolanes A and B, Two New Caryolane‐Type Sesquiterpenoids from Marine Streptomyces sp. AH25 (Chem. Biodiversity 12/2020),Chemistry & Biodiversity

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Front Cover: Micaryolanes A and B, Two New Caryolane‐Type Sesquiterpenoids from Marine Streptomyces sp. AH25 (Chem. Biodiversity 12/2020)
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-12-07 , DOI: 10.1002/cbdv.202000953
Jiequn Wu ₁ , Yuqin Zhu ₁ , Mengxue Zhang ₂ , Hongji Li ₂ , Peng Sun ₂

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Front Cover. Caryolanes known as β‐caryophyllene alcohols are widely occurring sesquiterpenes in plants. Two new caryolane‐type sesquiterpenes, micaryolane A and B (1 and 2), together with caryolan‐1,9β‐diol (3) were isolated from the cultures of marine Streptomyces sp. AH25. Their structures were elucidated by extensive analyses of HR‐MS and NMR spectroscopic data. The absolute configurations were determined by analyses of the CD data of in situ formed [Rh₂(OCOCF₃)₄] complex and supported by comparison of experimental specific optical rotations and calculated ones. Compounds 1 – 3 showed no inhibitory activities against Hep3B or MG‐63 cell lines or against Gram‐positive and Gram‐negative bacteria. These results have proved bacteria as a productive source of terpenoid metabolites as reported by J. Wu, Y. Zhu, M. Zhang, H. Li, and P. Sun in their full paper at10.1002/cbdv.202000769.

中文翻译：

封面：Micaryolanes A和B，来自海洋链霉菌属的两个新的Caryolane型倍半萜。AH25（化学生物多样性12/2020）

前盖。被称为β-叶绿素烯醇的卡里奥拉酮是植物中广泛存在的倍半萜。两个新的caryolane型倍半萜烯，micaryolane A和B（1和2）中，用caryolan -1,9-一起β -二醇（3）是从海洋的培养物中分离链霉菌属。AH25。通过对HR-MS和NMR光谱数据进行广泛分析，阐明了它们的结构。绝对构型是通过分析原位形成的[Rh ₂（OCOCF ₃）₄ ]络合物的CD数据确定的，并通过比较实验比旋光度和计算出的旋光度来支持。化合物1– 3对Hep3B或MG-63细胞系或革兰氏阳性和革兰氏阴性细菌没有抑制活性。这些结果证明细菌的代谢产物萜类化合物的生产来源，报道J.武，Y.朱，张M.，H.李和P.太阳在他们的论文全文at10.1002 / cbdv.202000769。

更新日期：2020-12-12

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