Single-drop microextraction (SDME) has been recognized as one of the simple miniaturized sample preparation tools for the isolation and preconcentration of several analytes from a complex sample matrix. In this review, we explored the applications of SDME coupled with various analytical techniques (spectroscopy, chromatography, and mass spectrometry) for the analysis of organic molecules, inorganic ions, and biomolecules from various sample matrices including food, environmental, clinical, pharmaceutical, and industrial samples. Also, it summarizes the use of nanoparticles in SDME combined with various analytical tools for the rapid analysis of several trace-level target analytes. An overview of ionic liquids, deep eutectic solvents, and SUPRAS, which improved the selectivity and sensitivity of various analytical techniques toward several analytes, as promising extracting solvent systems in SDME is also included. Finally, discussed the impressive analytical features and future perspectives of SDME in this review article.

单滴微萃取（SDME）已被认为是用于从复杂样品基质中分离和预富集多种分析物的简单小型样品制备工具之一。在这篇综述中，我们探索了SDME与各种分析技术（光谱学，色谱法和质谱法）相结合的应用，以分析来自食品，环境，临床，制药和食品等各种样品基质的有机分子，无机离子和生物分子。工业样品。此外，它总结了纳米粒子在SDME中的使用以及与各种分析工具的结合，用于快速分析几种痕量目标分析物。概述了离子液体，深共熔溶剂和SUPRAS，它们提高了各种分析技术对几种分析物的选择性和灵敏度，因为还包括SDME中很有希望的萃取溶剂系统。最后，在这篇评论文章中讨论了SDME令人印象深刻的分析功能和未来前景。