Multiple Osteochondroma is an abnormal skeleton development autosomal dominant genetic disease which caused by the mutation of EXT1 gene. In this study, we generated induced pluripotent stem cells (iPSCs) from the mesenchymal stem cells (MSCs) of a 12-year-old male patient by reprogramming MSCs with non-integrative vectors. The iPSCs line expresses pluripotent markers, has a normal male karyotype and can differentiate into the three germ layers.

中文翻译：

---

从携带EXT1突变的多个骨软骨瘤的男性中产生诱导性多能干细胞系SMBCi010-A

多发性骨软骨瘤是由EXT1基因突变引起的异常骨骼发育常染色体显性遗传疾病。在这项研究中，我们通过使用非整合型载体对MSCs进行重编程，从一名12岁男性患者的间充质干细胞（MSCs）中生成了诱导性多能干细胞（iPSC）。iPSCs系表达多能性标记，具有正常的男性核型，可以分化为三个胚层。