Introduction

Cognitive reserve can be defined as a property of the brain that enables an individual to sustain cognitive performance in spite of age-related neural changes. This study uses brain imaging to identify which cognitive reserve mechanisms protect against the detrimental effect of hippocampal atrophy on associative memory.

Methods

The study included 108 older adults from the Quebec Consortium for the early identification of Alzheimer’s disease. They received a magnetic resonance imaging examination to measure memory-related activations and hippocampal volume. Participants also completed a reserve-proxy questionnaire, and received a comprehensive clinical assessment.

Results

Higher scores on the reserve questionnaire were associated with more activation in the right inferior temporal and left occipital fusiform gyri. The activation of the right temporal gyrus moderated the relationship between the volume of the hippocampus and face-name memory. A smaller volume was associated with weaker memory in participants with lower activation, but not in those with greater activation.

Discussion

Recruitment of the temporal lobe protects against the detrimental effect of hippocampal atrophy on associative memory and contributes to cognitive reserve.

中文翻译：

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韧性与海马萎缩对记忆力影响的神经相关性

介绍

认知储备可以定义为大脑的一种属性，尽管年龄相关的神经变化，也可以使个体保持认知能力。这项研究使用大脑成像来确定哪些认知储备机制可以防止海马萎缩对联想记忆的有害影响。

方法

该研究包括来自魁北克财团的108位老年人，用于及早发现阿尔茨海默氏病。他们接受了磁共振成像检查，以测量与记忆有关的激活和海马体积。参加者还填写了一份备用代理问卷，并接受了全面的临床评估。

结果

保留问卷中较高的分数与右下颞和左枕梭状回的更多激活有关。右颞回的激活调节了海马体积与面部名字记忆之间的关系。较小的音量与较低激活水平的参与者的记忆力较弱有关，但与较高激活强度的参与者无关。

讨论区

颞叶的招募可以防止海马萎缩对联想记忆的有害影响，并有助于认知储备。