Background

While vibration therapy has shown encouraging results across many fields of medicine in the last decade, its role as originally envisioned for bone health remains uncertain. Especially regarding its efficacy in promoting fracture healing, mixed and incomplete outcomes suggest a need to clarify its potential. In particular, the definitive effect of vibration, when isolated from the confounding mechanical inputs of gait and stabilizing instrumentation, remains largely unknown.

Methods

Four cohorts of C57BL/6 male mice underwent single-leg, open fibula fracture. Vibration was applied at 0.3 g to two groups for 20 min/d. At 3 and 6 weeks, fibulae were harvested for microcomputed tomography and 3-point bending to failure.

Findings

In bone volume and tissue volume, the groups at each healing time point were statistically not different. At 3 weeks, however, the ratio of bone-to-tissue volume was lower for the vibrated group than control. Likewise, while bone mineral density did not differ, tissue volume density was lowest with vibration. At 6 weeks, mean differences were nominal. Biomechanically, vibration consistently trended ahead of control in strength and stiffness, but did not achieve statistical significance.

Interpretation

At this stage of therapeutic development, vibration therapy in isolation does not demonstrate a clear efficacy for bone healing, although further treatment permutations and translational uses remain open for investigation.

中文翻译：

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低强度振动治疗小鼠部分负重，非器械性长骨骨折模型的修复和重塑

背景

在过去的十年中，尽管振动疗法在许多医学领域都显示出令人鼓舞的结果，但其最初对骨骼健康的作用仍不确定。特别是就其在促进骨折愈合方面的功效而言，混杂和不完整的结果提示需要阐明其潜力。尤其是，当与步态和稳定仪器的混杂机械输入隔离开来时，振动的确定效果仍然未知。

方法

四组C57BL / 6雄性小鼠经历了单腿开放腓骨骨折。以0.3 g的振动向两组施加20分钟/天的振动。在第3周和第6周，收集腓骨用于微计算机断层扫描和3点弯曲至失败。

发现

在骨体积和组织体积上，各愈合时间点的组在统计学上没有差异。然而，在3周时，振动组的骨组织体积比低于对照组。同样，虽然骨矿物质密度没有差异，但随着振动，组织体积密度最低。在6周时，平均差异是名义上的。从生物力学上讲，振动在强度和刚度上始终趋于领先，但没有达到统计学意义。

解释

在治疗发展的这一阶段，尽管进一步的治疗方法排列和翻译用途仍有待研究，但单独的振动治疗尚无明显的骨愈合功效。