Lower esophageal sphincter muscle of patients with achalasia exhibits profound mast cell degranulation,Neurogastroenterology & Motility

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Lower esophageal sphincter muscle of patients with achalasia exhibits profound mast cell degranulation
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-12-06 , DOI: 10.1111/nmo.14055
Melissa Nelson ₁ , Xi Zhang ₁ , Robert M Genta _{2,

3} , Kevin Turner ₂ , Eitan Podgaetz ₄ , Shere Paris ₁ , Jacob Cardenas ₅ , Jinghua Gu ₅ , Steven Leeds ₆ , Marc Ward ₆ , Anh Nguyen ₁ , Vani Konda ₁ , Glenn T Furuta ₇ , Zui Pan ₈ , Rhonda F Souza ₁ , Stuart Jon Spechler ₁

Affiliation

Eosinophils and mast cells are key effectors of allergy. When they accumulate in the esophagus, their myoactive, pro‐inflammatory, and cytotoxic products potentially could cause achalasia‐like motility abnormalities and neuronal degeneration. We hypothesized that there is an allergy‐mediated form of achalasia.

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