The MHC class I-related protein, MR1, presents small metabolite antigens to an unusual subset of innate-like T cells. Herein, we highlight recent progress in our understanding of MR1’s unique antigen presenting pathway, with features of both MHC class I and class II antigen presentation, as highlighted during the EMBO Workshop: CD1-MR1, Beyond MHC-restricted lymphocytes, Oxford, 2019. There is increasing evidence for a role of MR1 restricted T cells in several immune contexts, from cancer to autoimmunity and infections, and therapeutic harnessing of this important biological axis through generation of agonist and antagonist MR1 ligands requires a thorough understanding of the molecular mechanisms of MR1-dependent antigen presentation.

MHC I类相关蛋白MR1将少量代谢物抗原呈递给先天样T细胞的异常子集。此处，我们重点介绍了我们对MR1独特抗原呈递途径的理解的最新进展，同时具有MHC I类和II类抗原呈递的特征，如EMBO研讨会期间所强调的：CD1-MR1，超越MHC限制的淋巴细胞，牛津，2019年。越来越多的证据表明MR1限制性T细胞在从癌症到自身免疫和感染等多种免疫环境中的作用，并且通过产生激动剂和拮抗剂MR1配体来治疗这一重要的生物轴需要对MR1的分子机制有透彻的了解。依赖性抗原呈递。