Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation.

鞘脂及其合成酶已成为许多疾病的关键介质，包括炎症、衰老和癌症。特别是一种酶，鞘氨醇激酶 (SK) 及其产物 1-磷酸鞘氨醇 (S1P)，已广泛参与这些过程。SK 催化鞘氨醇磷酸化为 S1P，并以两种异构体 SK1 和 SK2 的形式存在。在这篇综述中，我们将讨论 Lina M. Obeid 博士实验室的贡献，这些贡献定义了几种生物活性鞘脂在信号传导和疾病中的作用，重点是她在细胞命运和病理生物学中定义 SK1 的工作，包括增殖、衰老、细胞凋亡和炎症。