Chronic Kidney Disease (CKD) is a global health problem annually affecting millions of people around the world. It is a comprehensive syndrome, and various factors may contribute to its occurrence. In this study, it was attempted to provide an accurate definition of chronic kidney disease; followed by focusing and discussing on molecular pathogenesis, novel diagnosis approaches based on biomarkers, recent effective antigens and new therapeutic procedures related to high-risk chronic kidney disease such as membranous glomerulonephritis, focal segmental glomerulosclerosis, and IgA nephropathy, which may lead to end-stage renal diseases. Additionally, a considerable number of metabolites and proteins that have previously been discovered and recommended as potential biomarkers of various CKD_s using ‘-omics-’ technologies, proteomics, and metabolomics were reviewed.

中文翻译：

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慢性肾脏疾病：蛋白质组学和代谢组学方法对膜性肾小球肾炎，局灶性节段性肾小球硬化和IgA肾病生物标志物的综述

慢性肾脏病（CKD）是每年都会影响全球数百万人的全球性健康问题。它是一种综合症，可能受多种因素影响。在这项研究中，试图为慢性肾脏疾病提供准确的定义。随后，重点讨论分子发病机理，基于生物标志物的新诊断方法，近期有效的抗原以及与高危慢性肾脏病（如膜性肾小球肾炎，局灶性节段性肾小球硬化和IgA肾病）相关的新治疗方法，这些可能会导致阶段性肾脏疾病。此外，先前已发现并推荐大量代谢物和蛋白质作为各种CKD_的潜在生物标志物 使用“ -omics-”技术，对蛋白质组学和代谢组学进行了综述。