Colorectal Cancer (CRC) is ranked the third most common cancer in women and the fourth in men in Iran. Many factors contribute to CRC occurrence, and most of them are interrelated. The present study aimed to explore the spatial pattern of CRC incidence in Hamadan province, Iran. We collected and analyzed data on patients’ location, gender, age, and date of diagnosis recorded in the CRC registry between 2007 and 2014 in Hamadan province. The Anselin Local Moran’s I statistic was conducted to identify clusters and outliers of CRC distribution. There were 805 recorded CRC cases in Hamadan province during 2007–2014, with an incidence of 45.89 patients per 100,000 people. Three significant clusters of both high and low incidence rate were found in the study area. This research demonstrated significant geographical disparities in CRC incidence in Hamadan province. The spatial analysis of CRC incidence pattern generates new hypothesis on effect of location in disease clusters. These findings may shine light on underlying risk factors in areas where the CRC risk is greater and how contextual factors may play a role in CRC geographic disparity.

中文翻译：

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伊朗哈马丹省结直肠癌发病率的空间分析：回顾性跨部门研究

在伊朗，结直肠癌（CRC）在女性中排名第三，在男性中排名第四。导致CRC发生的因素很多，而且大多数是相互关联的。本研究旨在探讨伊朗哈马丹省CRC发病率的空间格局。我们收集并分析了哈马丹省2007年至2014年间CRC登记册中记录的患者位置，性别，年龄和诊断日期的数据。进行了Anselin Local Moran's I统计以识别CRC分布的聚类和离群值。2007-2014年，哈马丹省有805例记录的CRC病例，每100,000人中有45.89例患者。在研究区域中发现了三个高发率和低发率的重要集群。这项研究表明，在哈马丹省，CRC发病率存在巨大的地理差异。CRC发病模式的空间分析产生了关于疾病簇位置影响的新假设。这些发现可能会揭示CRC风险较大的地区的潜在风险因素，以及背景因素如何在CRC地理差异中发挥作用。