The exact calculation of the delivered dose in the process of irradiating tumors with proton and carbon ion beams is one of the most important components of the process of planning radiation therapy. Today there are two advanced microdosimetric models for calculation the relative biological efficacy of radiation, that are used in clinical practice. This is Microdosimetric Kinetic Model (MKM) and Local Effect Model (LEM). This paper contains descriptions of the features of the implementation of the MKM as model that is included in the RTS&T code system. The results of theoretical and experimental studies of the main microdosimetric characteristics for cellular structures placed in homogeneous water phantoms irradiated with 454 MeV/u ¹²C⁶⁺ ions are presented.

中文翻译：

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RTS＆T代码与微观动力学模型相结合，用于多离子治疗的生物学计算

在质子和碳离子束照射肿瘤的过程中准确计算输送剂量是规划放射治疗过程中最重要的组成部分之一。如今，有两种先进的微剂量模型可用于计算放射线的相对生物学功效，这些模型已在临床实践中使用。这是微剂量动力学模型（MKM）和局部效应模型（LEM）。本文包含对MKM作为RTS＆T代码系统中包含的模型的实现的功能的描述。提出了在454 MeV / u ¹² C ⁶⁺离子辐照的均质水体模中放置的细胞结构的主要微剂量学特性的理论和实验研究结果。