Abstract We studied the effects of whole body gamma-radiation (4 Gy, dose rate 0.6 Gy/min) and proton-beam head irradiation (with an energy of 150 meV, 4 Gy and a dose rate of 0.8 Gy/min) on the intensity and timing of audiogenic seizures in rats of the Krushinsky–Molodkina selected strain. In experiments using gamma rays the rat behavior was tested in the open field, elevated plus maze, and Morris water maze tests. No changes in audiogenic tonic–clonic seizures (originating in the brain stem) were found during the first exposure to sound after gamma-irradiation. Slower development of seizures and larger latency of the tonic seizure phase were found following serial daily exposure to sound in rats after proton irradiation. It was also noted that audiogenic myoclonic seizures (which developed in the forebrain) in irradiated rats that were exposed daily to sound had shorter durations, while the intensity of these seizures was at a maximum in all groups. The behavioral tests revealed a moderate increase in anxiety after radiation exposure.

中文翻译：

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电离辐射对 Krushinsky-Molodkina 大鼠听源性癫痫发作倾向和行为的影响

摘要 我们研究了全身伽马辐射（4 Gy，剂量率为 0.6 Gy/min）和质子束头部辐射（能量为 150 meV，4 Gy，剂量率为 0.8 Gy/min）对Krushinsky-Molodkina 选定品系大鼠听源性癫痫发作的强度和时间。在使用伽马射线的实验中，大鼠的行为在开阔场、高架十字迷宫和莫里斯水迷宫试验中进行了测试。在伽马射线照射后第一次接触声音期间，没有发现听源性强直-阵挛发作（起源于脑干）的变化。在质子照射后，大鼠每天连续接触声音后，发现癫痫发作的发展更慢，强直发作的潜伏期更长。还注意到，每天接触声音的受辐射大鼠的听源性肌阵挛发作（在前脑中发展）持续时间较短，而这些癫痫发作的强度在所有组中都达到最大值。行为测试显示辐射暴露后焦虑程度适度增加。