Synthesize new complexes of Ag(I) to enhance efficacy or stability and also, pharmacological activities on the operation of pyrazolone's biological properties. Efficient and high yielding pathways starting from the versatile and readily available 3-methyl-1-phenyl-5-pyrazolone by Knoevenagel condensation of a sequence of 4-arylidene-3-methyl-1-phenyl-5-pyrazolone derivatives (2a-c) have been formed by the reaction of various substituted aromatic aldehydes Used as ligands to synthesize Ag(I) chelates. Synthesized compounds and their complexes have been characterized by elemental analysis, magnetic and spectroscopic methods (IR, 13C, 1HNMR, mass) and thermal analysis. The spectrophotometric determinations suggest distorted octaedral geometry for all complexes. Both ligands and their metal complexes have also been tested for their antibacterial and antifungal efficacy. Newly synthesized compounds have shown potent antimicrobial activity. The results showed that the complex 's high activity was higher than its free ligands, and that Ag(I)-L3 had the highest activity.

中文翻译：

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吡唑啉酮衍生物的银（I）配合物的光谱，热，抗菌研究

合成新的Ag（I）配合物以增强功效或稳定性，并提高吡唑啉酮生物学特性的药理活性。高效且高产的途径从通用且易于获得的3-甲基-1-苯基-5-吡唑啉酮通过一系列4-芳叉基-3-甲基-1-甲基-1-苯基-5-吡唑啉酮衍生物（2a-c ）是通过用作配体合成Ag（I）螯合物的各种取代的芳香醛反应形成的。合成的化合物及其配合物已通过元素分析，磁性和光谱法（IR，13C，1HNMR，质量）和热分析进行了表征。分光光度法测定表明所有配合物的八面体几何形状均发生了扭曲。还已经测试了配体及其金属配合物的抗菌和抗真菌功效。新合成的化合物显示出有效的抗菌活性。结果表明，该配合物的高活性高于其游离配体，并且Ag（I）-L3的活性最高。