Mulberry leaf attenuates atherosclerotic lesions in patients with coronary heart disease possibly via 1‐Deoxynojirimycin: A placebo‐controlled, double‐blind clinical trial,Journal of Food Biochemistry

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Mulberry leaf attenuates atherosclerotic lesions in patients with coronary heart disease possibly via 1‐Deoxynojirimycin: A placebo‐controlled, double‐blind clinical trial
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-12-05 , DOI: 10.1111/jfbc.13573
Yuting Wang ₁ , Zhongwei Yu ₂ , Jun Jiang ₁ , Yaxin Li ₁ , Shui Yu ₁

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Mulberry leaf tea reduces atherosclerotic lesions and its main component is Deoxynojirimycin (DNJ). We aimed to explore the effects of Mulberry leaf DNJ (MLD) on atherosclerotic lesions in the patients with coronary heart disease (CHD). MLD and serum DNJ was detected by high‐performance liquid chromatography (HPLC). The CHD patients with low‐density lipoprotein cholesterol >140 mg/dl were assigned into the EG (MLD treatment) and the CG (placebo treatment) groups. Serum biochemical indices, the cerebrovascular and cardiovascular events and carotid intima‐media thickness (IMT) were measured before and after a 1‐year intervention. Pearson Correlation Coefficient test was used to explore the relationship between serum levels of DNJ and IMT values. Serum DNJ was 70 ± 50 ng/ml in the EG group but no serum DNJ was detected in the CG group. The incidence of cerebrovascular and cardiovascular events in the EG was lower than that in the CG group (p < .05). MLD therapy improved antioxidant and anti‐inflammatory properties and serum lipid profile (p < .05). The IMT values in the EG group were lower than those in the CG group (p < .05). Serum levels of DNJ had a strong negative relationship with IMT values. MLD treatment attenuates atherosclerotic lesions possibly via DNJ.

中文翻译：

桑叶可能通过1-脱氧野oji霉素治疗减轻冠心病患者的动脉粥样硬化病变：一项安慰剂对照的双盲临床试验

桑叶茶可减轻动脉粥样硬化病变，其主要成分是脱氧野rim霉素（DNJ）。我们旨在探讨桑叶DNJ（MLD）对冠心病（CHD）患者的动脉粥样硬化病变的影响。通过高效液相色谱（HPLC）检测MLD和血清DNJ。低密度脂蛋白胆固醇> 140 mg / dl的冠心病患者分为EG（MLD治疗）和CG（安慰剂治疗）组。干预前后一年，测量血清生化指标，脑血管和心血管事件以及颈动脉内膜中层厚度（IMT）。皮尔逊相关系数检验用于探讨血清DNJ水平与IMT值之间的关系。EG组的血清DNJ为70±50 ng / ml，而CG组未检测到血清DNJ。p <.05）。MLD治疗改善了抗氧化和抗炎特性以及血脂水平（p <.05）。EG组的IMT值低于CG组的IMT值（p <.05）。血清DNJ水平与IMT值呈强烈负相关。MLD治疗可能通过DNJ减轻动脉粥样硬化病变。

更新日期：2021-01-19

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