Background

Cognitive deficits are associated with asthma globally; however, the association between cognitive function and asthma has not been fully elucidated.

Objective

To assess the relationship between asthma and cognitive function.

Methods

A total of 202 patients with asthma aged older than 18 years were analyzed retrospectively from August 2019 to February 2020. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) test. We compared the associations of clinical parameters with cognitive function (MoCA, ≥23 vs <23) and lung function (forced expiratory volume in 1 second [FEV1], ≥70% vs <70%).

Results

Of the total participants, 89 (44.1%) indicated cognitive impairment, of whom

23.1% were aged less than 65 years and 72.9% were aged 65 years or older. MoCA scores were significantly different according to age (24.91 ± 3.89 for ages <65 years vs 19.11 ± 5.11 for ages ≥65 years, P < .001) and lung function (23.29 ± 5.17 for FEV1 ≥70% vs 21.23 ± 5.21 for FEV1 <70%, P = .006), but not according to asthma control (22.35 ± 5.38 for nonsevere asthma vs 22.88 ± 4.91 for severe asthma, P = .55). Age (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.014-1.13; P = .01), educational status (OR, 6.068; CI, 2.175-16.927; P = .001), and asthma duration (OR, 1.007; CI, 1.001-1.013; P = .02) were significantly associated with cognitive impairment.

Conclusion

Cognitive impairment was largely observed in adults (44.1%) with asthma and was more prevalent in older adults than in younger adults. Longer asthma duration and lower lung function were more associated with cognitive dysfunction.

中文翻译：

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成人认知功能与哮喘的关系

背景

认知缺陷与全球哮喘有关；但是，尚未完全阐明认知功能与哮喘之间的关系。

目的

评估哮喘与认知功能之间的关系。

方法

从2019年8月至2020年2月，对202例18岁以上的哮喘患者进行了回顾性分析。使用蒙特利尔认知评估（MoCA）测试评估认知功能。我们比较了临床参数与认知功能（MoCA，≥23vs <23）和肺功能（1秒内呼气量[FEV1]，≥70％vs <70％）之间的关联。

结果

在所有参与者中，有89名（44.1％）表示认知障碍，其中

65岁以下的人群占23.1％，65岁以上的人群占72.9％。MoCA分数因年龄而异（<65岁年龄段为24.91±3.89，≥65岁年龄段为19.11±5.11，P <.001）和肺功能（FEV1≥70％时为23.29±5.17，而FEV1为21.23±5.21 <70％，P  = .006），但未根据哮喘控制（非严重哮喘为22.35±5.38，而严重哮喘为22.88±4.91，P  = .55）。年龄（优势比[OR]为1.07； 95％置信区间[CI]为1.014-1.13；P  = 0.01），教育状况（OR为6.068； CI为2.175-16.927；P  = 0.001）和哮喘病持续时间（OR，1.007; CI，1.001-1.013; P  = .02）与认知障碍显着相关。

结论

在患有哮喘的成年人中（44.1％）在很大程度上观察到了认知障碍，并且老年人比年轻人更普遍。较长的哮喘病持续时间和较低的肺功能与认知功能障碍相关。