Fungal diseases contribute significantly to morbidity and mortality in humans. Although recent research has improved our understanding of the complex and dynamic interplay that occurs between pathogenic fungi and the human host, much remains to be elucidated concerning the molecular mechanisms that drive fungal pathogenicity and host responses to fungal infections. In recent times, there has been a significant increase in studies investigating the immunological functions of microbial-induced host cell death. In addition, pathogens use many strategies to manipulate host cell death pathways to facilitate their survival and dissemination. This review will focus on the mechanisms of host programmed cell death that occur during opportunistic fungal infections, and explore how cell death pathways may affect immunity towards pathogenic fungi.

真菌疾病显着导致人类发病率和死亡率。尽管最近的研究提高了我们对病原真菌与人类宿主之间发生的复杂和动态相互作用的理解，但关于驱动真菌致病性和宿主对真菌感染的反应的分子机制仍有许多待阐明。近年来，研究微生物诱导的宿主细胞死亡的免疫功能的研究显着增加。此外，病原体使用许多策略来操纵宿主细胞死亡途径，以促进其生存和传播。本综述将重点关注机会性真菌感染期间发生的宿主程序性细胞死亡机制，并探讨细胞死亡途径如何影响对病原真菌的免疫。