In this work, supercritical phase inversion was used to produce membranes of cellulose acetate, loaded with a highly hydrophobic drug, quercetin, with antifungal properties. Changing process parameters, such as polymer concentration (5%, 10% and 15% w/w), pressure (100 and 200 bar) and temperature (45 and 50 °C), different membrane morphologies and pores size were obtained. Operating in this way, it was possible to control quercetin release: the existence of macrovoids (i.e., finger-like structure) promoted a faster drug release (about 200 min); whereas, cellular structures favored a prolonged drug release (up to 1400 min). These membranes were tested against two types of fungi (Kluyveromyces lactis and Yarrowia lipolitica), obtaining an efficient and prolonged antifungal effect, overcoming the problems of quercetin hydrophobicity.

在这项工作中，超临界相转化用于生产醋酸纤维素膜，该膜负载有具有抗真菌特性的高度疏水性药物槲皮素。改变了工艺参数，例如聚合物浓度（5％，10％和15％w / w），压力（100和200 bar）和温度（45和50°C），不同的膜形态和孔径。以这种方式操作，就有可能控制槲皮素的释放：大孔（即手指状结构）的存在促进了更快的药物释放（约200分钟）。然而，细胞结构有利于延长药物释放（长达1400分钟）。这些膜针对两种类型的真菌（乳酸克鲁维酵母和脂耶氏酵母）进行了测试。），获得了有效而持久的抗真菌作用，克服了槲皮素疏水性的问题。