Abstract The efficacy of weight loss interventions might be affected by the metabolic profile of adolescents with obesity. In this study, we hypothesize that the initial diagnosis of the MS, or its persistence after an intervention, will not reduce the efficacy of a 16-week multidisciplinary weight loss program. 92 adolescents (12-15 years; 62 girls) with obesity completed baseline anthropometric and body composition evaluation (DXA). Lipid profile, insulinemia, glycaemia and blood pressure were measured and MS diagnosed. The adolescents then followed a 4-month inpatient multidisciplinary weight-management program. All measurements were performed before (T0) and after 4 months of intervention (T1). Body weight, body mass index (BMI) and percentage of fat mass (%FM) decreased significantly between T0 and T1 (p

中文翻译：

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多学科减肥干预的心脏代谢功效在最初诊断为肥胖或患有持续代谢综合征的青少年中没有改变

摘要 肥胖青少年的代谢特征可能会影响减肥干预的效果。在本研究中，我们假设 MS 的初步诊断或干预后的持续存在不会降低 16 周多学科减肥计划的效果。92 名肥胖青少年（12-15 岁；62 名女孩）完成了基线人体测量和身体成分评估 (DXA)。测量血脂、胰岛素血症、血糖和血压并诊断 MS。这些青少年随后接受了为期 4 个月的住院多学科体重管理计划。所有测量均在干预前 (T0) 和干预 4 个月后 (T1) 进行。体重、体重指数 (BMI) 和脂肪量百分比 (%FM) 在 T0 和 T1 之间显着下降（p