OBJECTIVE To compare the risk of adverse neonatal outcomes after frozen embryo transfer (FET) among women with polycystic ovary syndrome (PCOS) with those among women without PCOS. DESIGN Retrospective cohort study. SETTING Tertiary-care academic medical center. PATIENT(S) In this study, we included 1,167 singletons born to mothers with PCOS and 9,995 singletons born to mothers without PCOS after FET during the period from January 1, 2007, to December 31, 2019. INTERVENTION(S) None. MAIN OUTCOMES MEASURE(S) Adverse neonatal outcomes including preterm birth, low birth weight, high birth weight, small for gestational age (SGA), and large for gestational age. RESULT(S) The odds of preterm birth were significantly higher among infants from mothers with PCOS compared with those from mothers without PCOS. The odds of low birth weight and SGA were lower in mothers with PCOS compared with mothers without PCOS in the overall analysis, but the differences in low birth weight and SGA between mothers with and without PCOS did not exist in the subgroup analysis with a normal BMI population. CONCLUSION(S) The diagnosis of PCOS was independently associated with increased odds of preterm birth among women with singleton pregnancies by FET. In addition, decreased odds of low birth weight and SGA were observed among patients with PCOS, but the increased odds were not observed in the subset analysis of patients with PCOS with normal BMI.

中文翻译：

---

冻融胚胎移植后多囊卵巢综合征妇女的新生儿结局

目的 比较多囊卵巢综合征 (PCOS) 女性与非 PCOS 女性冷冻胚胎移植 (FET) 后新生儿不良结局的风险。设计 回顾性队列研究。设置三级护理学术医疗中心。患者 在本研究中，我们纳入了 2007 年 1 月 1 日至 2019 年 12 月 31 日期间 FET 后患有 PCOS 的母亲所生的 1,167 名单胎和 9,995 名非 PCOS 母亲所生的单胎。 干预（S） 无。主要结局指标 不良新生儿结局包括早产、低出生体重、高出生体重、小于胎龄 (SGA) 和大于胎龄。结果 与没有 PCOS 的母亲相比，患有 PCOS 的母亲所生婴儿的早产几率显着更高。在总体分析中，PCOS 母亲与非 PCOS 母亲相比，低出生体重和 SGA 的几率较低，但在 BMI 正常的亚组分析中，PCOS 母亲和非 PCOS 母亲之间的低出生体重和 SGA 差异不存在人口。结论 (S) PCOS 的诊断与 FET 单胎妊娠妇女早产几率增加独立相关。此外，在 PCOS 患者中观察到低出生体重和 SGA 的几率降低，但在 BMI 正常的 PCOS 患者的亚组分析中未观察到增加的几率。但在正常 BMI 人群的亚组分析中，患有和不患有 PCOS 的母亲在低出生体重和 SGA 方面的差异不存在。结论 (S) PCOS 的诊断与 FET 单胎妊娠妇女早产几率增加独立相关。此外，在 PCOS 患者中观察到低出生体重和 SGA 的几率降低，但在 BMI 正常的 PCOS 患者的亚组分析中未观察到增加的几率。但在正常 BMI 人群的亚组分析中，患有和不患有 PCOS 的母亲在低出生体重和 SGA 方面的差异不存在。结论 (S) PCOS 的诊断与 FET 单胎妊娠妇女早产几率增加独立相关。此外，在 PCOS 患者中观察到低出生体重和 SGA 的几率降低，但在 BMI 正常的 PCOS 患者的亚组分析中未观察到增加的几率。