Atovaquone belongs to a naphthoquinone class of drugs and is used in combination with proguanil (Malarone) for the treatment of acute, uncomplicated malaria caused by Plasmodium falciparum (including chloroquine-resistant P. falciparum/P. vivax). Numerous quinone-derived compounds have attracted considerable attention in the last few decades due to their potential in antimalarial drug discovery. Several semi-synthetic derivatives of natural quinones, synthetic quinones (naphtho-/benzo-quinone, anthraquinones, thiazinoquinones), and quinone-based hybrids were explored for their in vitro and in vivo antimalarial activities. A careful literature survey revealed that this topic has not been compiled as a review article so far. Therefore, we herein summarise the recent discovery (the year 2009–2020) of quinone based antimalarial compounds in chronological order. This compilation would be very useful towards the exploration of novel quinone-derived compounds against malarial parasites with promising efficacy and lesser side effects.

Atovaquone属于萘醌类药物，与鸟嘌呤（Malarone）组合用于治疗由恶性疟原虫（包括对氯喹耐药的恶性疟原虫/间日疟原虫）引起的急性，简单的疟疾。在过去的几十年中，由于醌类化合物具有抗疟疾药物的潜力，因此引起了人们的广泛关注。研究了天然醌，合成醌（萘醌/苯醌，蒽醌，噻嗪酮）和醌基杂化物的几种半合成衍生物的体内和体外研究。抗疟疾活动。仔细的文献调查显示，到目前为止，该主题尚未被整理为评论文章。因此，我们在此按时间顺序总结了基于醌的抗疟化合物的最新发现（2009-2020年）。该汇编对于探索新型的醌衍生化合物对抗疟原虫具有非常有效的功效和较小的副作用，将非常有用。