Climate change threatens global sustainability, especially in rural communities of developing countries. In Pakistan, severe impacts of climate change have become evident in the recent past. Large-scale floods in the Indus river system have caused massive damages in the past decade. Also, frequent droughts and heatwaves are among other consequences of the changing climate in the country. Understanding the perspective of local communities regarding climate change adaptation strategies is pivotal to effective policymaking. We surveyed the rural community in the Indus Basin, in southern Punjab, Pakistan, to assess the climate change adaptations currently practiced. We found that the respondents perceive droughts, floods, and disease outbreaks (which are frequently followed by flooding events) as major climate change-induced threats. The respondents used flood and drought-resistant crop varieties, field boundaries (spate irrigation), migration to safe places, and loans as key adaptation strategies. We also assessed the socioeconomic determinants of climate change adaptation behaviour using a binary logistic regression model. Gender, occupation, and education influenced the adaptations to climate change. The present study highlights the need for monetary support to flood-prone communities, better medical facilities, provision of drought and flood-resistant crop varieties, and awareness campaigns to enhance adaptive capacity in the study area.