PURPOSE The existing evidence of the potential applications and benefits of stem cell transplantation (SCT) in people with epilepsy and also its adverse effects in humans were systematically reviewed. METHODS MEDLINE (accessed from PubMed), Google Scholar, and Scopus from inception to August 17, 2020 were systematically reviewed for related published manuscripts. The following key words (in the title) were used: "stem cell" AND "epilepsy" OR "seizure". Articles written in English that were human studies on stem cell transplantation in people with epilepsy were all included. RESULTS We could identify six related articles. Because of their different methodologies, performing a meta-analysis was not feasible; they included 38 adults and 81 pediatric patients together. Five studies were single-arm human studies; there were no serious adverse events in any of the studies. CONCLUSION While stem cell transplantation seems like a promising therapeutic option for patients with drug-resistant epilepsy, data on its application is scarce and of low quality. For now, clinical stem cell-based interventions are not justified. Perhaps, in the future, there will be a rigorous and intensely scrutinized clinical trial protocol with informed consent that could provide enough scientific merit and could meet the required ethical standards.

中文翻译：

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癫痫患者的干细胞治疗：系统评价

目的 系统地回顾了干细胞移植 (SCT) 在癫痫患者中的潜在应用和益处及其对人类的不利影响的现有证据。方法 MEDLINE（从 PubMed 访问）、Google Scholar 和 Scopus 从成立到 2020 年 8 月 17 日，系统地审查了相关已发表的手稿。使用了以下关键词（在标题中）：“干细胞”和“癫痫”或“癫痫”。用英文写的关于癫痫患者干细胞移植的人体研究的文章都被收录。结果 我们可以确定六篇相关文章。由于他们的方法不同，进行荟萃分析是不可行的。他们包括 38 名成人和 81 名儿科患者。五项研究是单臂人体研究；在任何研究中都没有严重的不良事件。结论 尽管干细胞移植对于耐药性癫痫患者来说似乎是一种很有前景的治疗选择，但其应用数据很少且质量低下。目前，基于临床干细胞的干预措施是不合理的。或许，在未来，会有一个严格且经过严格审查的临床试验方案，在知情同意的情况下，可以提供足够的科学价值并符合所需的道德标准。