Antipsychotic (AP) medications are associated with an increased risk for developing metabolic side effects including weight gain, dyslipidemia, hypertension, type 2 diabetes (T2D), and cardiovascular disease. Previous reviews have focused on the chronic metabolic side effects associated with AP use. However, an underappreciated aspect of APs are the rapid perturbations in glucose and lipid metabolism that occur with each dose of drug. The purpose of this narrative review is to summarize work examining the peripheral mechanisms of acute olanzapine-induced related metabolic disturbances. We also discuss recent studies that have attempted to elucidate treatment approaches to mitigate AP-induced impairments in fuel metabolism.

抗精神病 (AP) 药物与发生代谢副作用的风险增加有关，包括体重增加、血脂异常、高血压、2 型糖尿病 (T2D) 和心血管疾病。以前的评论集中在与 AP 使用相关的慢性代谢副作用。然而，APs 的一个被低估的方面是葡萄糖和脂质代谢的快速扰动，每剂量药物都会发生。这篇叙述性评论的目的是总结研究急性奥氮平引起的相关代谢紊乱的外周机制的工作。我们还讨论了最近的研究，这些研究试图阐明减轻 AP 引起的燃料代谢障碍的治疗方法。