Background

After several decades of increasing incidence of papillary thyroid cancer (PTC), a change in this trend has been recently observed, particularly in the United States. This is attributed to the impact of new guidelines for the management of thyroid disease. The objective of this study was to describe the recent situation in France in terms of incidence and survival, taking account of tumor size.

Methods

Data from the FRANCIM network cancer registries, covering around 25% of the French metropolitan population, were analyzed. Distribution according to tumor size was determined in terms of frequency, trends in incidence and spatial distribution for the period 2008–2016. Analysis of net survival considered gender, age and tumor size.

Results

Cancers of size ≤ 5 mm were predominant in patients diagnosed between 55 and 74 years of age. Incidence of ≤ 5 mm tumors in women and of 5–10 mm tumors in men began declining in the early 2010s. Incidence of 10–20 mm and 20–40 mm tumors in men increased significantly throughout the period 2008–2016. For both men and women, the incidence of the largest tumors (> 40 mm) also increased, but not significantly. The spatial distribution of incidence showed great heterogeneity. Net survival was generally high, although decreasing with age and tumor size.

Conclusion

The recent epidemiological situation in France is consistent with the hypothesis of recent progress in medical management of thyroid pathologies. Variations in incidence should be monitored for both small (< 10 mm) and larger tumors, and notably > 40 mm tumors. Net survival is generally high, although decreasing with age and tumor size.

中文翻译：

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法国 2008 年至 2016 年间诊断出的甲状腺乳头状癌的发病率进展和净存活率估计

背景

经过几十年的甲状腺乳头状癌 (PTC) 发病率增加，最近观察到这种趋势的变化，特别是在美国。这归因于甲状腺疾病管理新指南的影响。本研究的目的是描述法国最近在发病率和生存率方面的情况，同时考虑到肿瘤大小。

方法

来自 FRANCIM 网络癌症登记处的数据进行了分析，该登记处覆盖了大约 25% 的法国大都市人口。根据肿瘤大小的分布是根据 2008-2016 年期间的频率、发病率趋势和空间分布确定的。考虑性别、年龄和肿瘤大小的净存活分析。

结果

大小 ≤ 5 毫米的癌症在诊断为 55 至 74 岁的患者中占主导地位。女性≤ 5 毫米肿瘤和男性 5-10 毫米肿瘤的发病率在 2010 年代初开始下降。在 2008-2016 年期间，男性 10-20 毫米和 20-40 毫米肿瘤的发病率显着增加。对于男性和女性，最大肿瘤（> 40 毫米）的发生率也有所增加，但不显着。发病的空间分布表现出很大的异质性。净存活率普遍较高，但随着年龄和肿瘤大小而降低。

结论

法国最近的流行病学情况与最近甲状腺病理医学管理取得进展的假设一致。对于小（< 10 mm）和更大的肿瘤，尤其是 > 40 mm 的肿瘤，都应监测发生率的变化。净存活率通常很高，但随着年龄和肿瘤大小而降低。