Subjects with alcohol use disorder (AUD) display a high prevalence of cardiovascular risk factors (CRFs), a high incidence of cardiovascular diseases associated with an earlier mortality. Abstinence has long-term cardiovascular and global health benefits. However, few studies have examined the short-term effect of alcohol cessation on cardiac function and key CRFs.

The aim of the study was to assess brain natriuretic peptide (BNP) and other CRFs on admission for alcohol cessation and 12 days later, in inpatient with AUD.

A retrospective chart review of inpatients hospitalized for alcohol cessation was conducted. Patients who did not relapse at day-12 were included. We compared, at entry and day-12, BNP and other CRFs: hemodynamic and electromyographic variables, lipid, homocysteine level and liver enzymes at entry and day-12. Wilcoxon, Student tests and repeated measures ANOVA were conducted.

Fifty-five patients were included (38 males, mean age 50.5 years, alcohol per day 60g to 750g, 44 current tobacco smokers). BNP was significantly increased (11.8pg/mL [±16.2] to 35.5pg/mL [±47.6], p<0.001). Repeated measure ANOVA showed a significant between-subject effect (p=0.024) but no significant interaction between BNP variation and having a BNP at entry > 10 pg/mL (p=0.092). In contrast, a significant improvement on 8 of 13 other CRFs and liver enzymes measures was observed (p≤0.05).

A rapid improvement of several CRFs is confirmed. However the increase of BNP at day 12 supports its investigation as a possible relevant biomarker of cardiac function in alcohol withdrawal.

患有酒精使用障碍 (AUD) 的受试者表现出心血管危险因素 (CRF) 的高患病率，心血管疾病的高发病率与较早的死亡率相关。禁欲具有长期心血管和全球健康益处。然而，很少有研究检查戒酒对心脏功能和关键 CRF 的短期影响。

该研究的目的是评估因戒酒入院时和 12 天后 AUD 住院患者的脑钠肽 (BNP) 和其他 CRF。

对因戒酒住院的住院患者进行了回顾性图表审查。包括在第 12 天未复发的患者。我们在进入和第 12 天比较了 BNP 和其他 CRF：血液动力学和肌电图变量、脂质、同型半胱氨酸水平和进入和第 12 天的肝酶。进行了 Wilcoxon、Student 检验和重复测量方差分析。

包括 55 名患者（38 名男性，平均年龄 50.5 岁，每天饮酒 60 至 750 克，44 名目前吸烟者）。BNP 显着增加（11.8pg/mL [±16.2] 至 35.5pg/mL [±47.6]，p<0.001）。重复测量方差分析显示出显着的受试者间效应 (p=0.024)，但 BNP 变异与进入时 BNP > 10 pg/mL (p=0.092) 之间没有显着相互作用。相比之下，观察到 13 项其他 CRF 和肝酶测量中的 8 项有显着改善（p≤0.05）。

确认了几个 CRF 的快速改进。然而，第 12 天 BNP 的增加支持将其作为酒精戒断心功能的可能相关生物标志物进行研究。