Perfluorooctanoic acid (PFOA) and related chemicals among the per- and polyfluoroalkyl substances are widely distributed in the environment. Adverse health effects may occur even at low exposure levels. A large-scale contamination of drinking water resources, especially the rivers Möhne and Ruhr, was detected in North Rhine-Westphalia, Germany, in summer 2006. As a result, concentration data are available from the water supply stations along these rivers and partly from the water network of areas supplied by them. Measurements started after the contamination’s discovery. In addition, there are sparse data from stations in other regions. Further information on the supply structure (river system, station-to-area relations) and expert statements on contamination risks are available. Within the first state-wide environmental-epidemiological study on the general population, these data are temporally and spatially modelled to assign estimated exposure values to the resident population. A generalized linear model with an inverse link offers consistent temporal approaches to model each station’s PFOA data along the river Ruhr and copes with a steeply decreasing temporal data pattern at mainly affected locations. The river’s segments between the main junctions are the most important factor to explain the spatial structure, besides local effects. Deductions from supply stations to areas and, therefore, to the residents’ risk are possible via estimated supply proportions. The resulting potential correlation structure of the supply areas is dominated by the common water supply from the Ruhr. Other areas are often isolated and, therefore, need to be modelled separately. The contamination is homogeneous within most of the areas.

全氟烷基物质和多氟烷基物质中的全氟辛酸（PFOA）和相关化学物质广泛分布于环境中。即使在低暴露水平下，也会对健康产生不利影响。2006年夏季，在德国北莱茵-威斯特法伦州发现了大规模的饮用水资源污染，特别是莫恩河和鲁尔河。因此，可从这些河流沿线的供水站获得浓度数据，部分可从他们提供的区域的供水网络。发现污染后开始测量。另外，来自其他地区的站点的数据稀疏。提供有关供应结构（河流系统，站点间关系）的更多信息以及有关污染风险的专家声明。在第一项针对普通人群的全州环境流行病学研究中，对这些数据进行时空建模，以将估计的暴露值分配给常住人口。具有反向链接的广义线性模型提供了一致的时域方法，可以对鲁尔河沿岸的每个电台的PFOA数据进行建模，并应对主要受影响地区急剧下降的时域数据模式。除局部影响外，主要交汇处之间的河段是解释空间结构的最重要因素。通过估计的供应比例，可以从供应站扣除费用，从而减少居民的风险。供水区域所产生的潜在相关结构主要由鲁尔河的普通供水所决定。其他地区通常是孤立的，因此，需要分别建模。在大多数区域内，污染物是均匀的。