In recent years, nanomaterials with properties such as biocompatibility, high specific surface area, and narrow pore distribution have been extensively studied for the treatment of cancer patients. These materials can be loaded with anti-tumor agents to promote a targeted delivery of drugs, reducing the occurrence of side effects common in conventional treatments. However, the ideal characteristics for biomedical applications are not often found combined in a single material, causing the need for the creation of systems composed of more phases to achieve the best material for such applications. Mesoporous silica nanoparticles are promising materials for this purpose, considering the possibility to incorporate organic and inorganic phases into this matrix, such as sensitive polymers, hydroxyapatite (HA) nanoparticles, and rare-earth elements, creating a theranostic material—a single hybrid compound with multifunctionality and capable of performing diagnostic and treatment functions simultaneously. In this study, we report the production of a europium-doped mesoporous silica/hydroxyapatite nanocomposite functionalized with the pH-sensitive polymer poly(methacrylic acid)—P(MAA). The samples were characterized by XRD, FTIR, CHN, TGA, SEM, TEM, XRF, N₂ adsorption, and PL techniques. Incorporation and release assays using the antitumor drug methotrexate were performed to evaluate the potential use of these materials as drug carriers in cancer therapy. The results show the photoluminescent potential of these systems, due to the europium doping, and the pH-dependent response in drug release, due to the P(MAA) functionalization. In conclusion, data from this work show that these hybrid nanocomposites exhibit adequate characteristics to be used as a drug delivery platform.

近年来，已经广泛研究了具有诸如生物相容性，高比表面积和狭窄的孔分布的性质的纳米材料以治疗癌症患者。可以在这些材料中加入抗肿瘤剂，以促进药物的靶向递送，减少常规治疗中常见的副作用的发生。然而，生物医学应用的理想特性通常不会发现结合在单一材料中，因此需要创建由更多相组成的系统，以获得用于此类应用的最佳材料。考虑到将有机相和无机相掺入该基质的可能性，如敏感聚合物，羟基磷灰石（HA）纳米颗粒和稀土元素，介孔二氧化硅纳米颗粒是用于该目的的有前途的材料，创造了治疗疗法材料-一种具有多种功能并能够同时执行诊断和治疗功能的杂化化合物。在这项研究中，我们报道了用pH敏感聚合物聚（甲基丙烯酸）-P（MAA）功能化的euro掺杂介孔二氧化硅/羟基磷灰石纳米复合材料的生产。通过XRD，FTIR，CHN，TGA，SEM，TEM，XRF，N表征样品₂吸附和PL技术。进行了使用抗肿瘤药甲氨蝶呤的掺入和释放试验，以评估这些材料在癌症治疗中作为药物载体的潜在用途。结果表明，由于systems的掺杂，这些系统的光致发光潜能；由于P（MAA）的功能化，药物释放中的pH依赖性响应。总之，这项工作的数据表明，这些杂化纳米复合材料具有足够的特性，可以用作药物递送平台。