Probiotics are used as a means to improve animal health and intestinal development. Saccharomyces boulardii is a well-known probiotic; however, few studies have examined the effects of S. boulardii on weaned piglet performance. Therefore, this 28-day study compared the effects of S. boulardii mafic-1701 and aureomycin in diets for weaned piglets on growth performance, antioxidant parameters, inflammation and intestinal microbiota. One hundred and eight piglets, weaned at 28 d of age (8.5 ± 1.1 kg), were randomly divided into the three dietary treatment groups with six pens and six piglets per pen (half male and half female). The dietary treatment groups were as follows: 1) basal diet (CON); 2) basal diet supplemented with 75 mg/kg aureomycin (ANT); 3) basal diet supplemented with 1 × 108 CFU/kg S. boulardii mafic-1701 (SB). Compared to CON group, SB group had higher feed efficiency (P < 0.05) in the last 14 d and lower diarrhea rate (P < 0.05) over the entire 28 d. Total superoxide dismutase in serum was markedly increased in SB group (P < 0.05). Moreover, compared with CON group, SB group decreased the levels of pro-inflammatory cytokines interleukin-6 (P < 0.01) and Tumor necrosis factor-α (P < 0.05) in jejunum. Supplementation of S. boulardii mafic-1701 increased the abundance of Ruminococcaceae_UCG_009 and Turicibacter (P < 0.05), whereas the abundance of unclassified_Clostridiaceae_4 was decreased (P < 0.05). Furthermore, S. boulardii mafic-1701 administration increased cecal concentration of microbial metabolites, isobutyrate and valerate (P < 0.05). The improvement in feed conversion ratio, reduction in diarrhea rate in weaned piglets provided diets supplemented with S. boulardii mafic-1701 may be associated with enhanced antioxidant activity, anti-inflammatory responses and improved intestinal microbial ecology.

中文翻译：

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在断奶仔猪中施用Saccharomyces boulardii mafic-1701可提高饲料转化率，增强抗氧化能力，减轻肠道炎症并调节肠道菌群

益生菌被用作改善动物健康和肠道发育的手段。酿酒酵母是一种众所周知的益生菌。然而，很少有研究检查过猪链球菌对断奶仔猪生产性能的影响。因此，这项为期28天的研究比较了断奶仔猪日粮中的S. boulardii mafic-1701和金霉素对生长性能，抗氧化剂参数，炎症和肠道菌群的影响。在28日龄断奶（8.5±1.1千克）的108头仔猪被随机分为三个饮食处理组，每只仔猪有6头，每头仔猪有6头（雄性一半，雌性一半）。饮食治疗组如下：1）基础饮食（CON）；2）基础饮食中补充75 mg / kg金霉素（ANT）；3）基础饮食中补充1×108 CFU / kg猪链球菌黑手党1701（SB）。与CON组相比 SB组在最后14 d的饲料效率更高（P <0.05），而在整个28 d的腹泻率较低（P <0.05）。SB组血清总超氧化物歧化酶明显升高（P <0.05）。此外，与CON组相比，SB组降低了空肠促炎细胞因子白细胞介素6（P <0.01）和肿瘤坏死因子-α（P <0.05）的水平。补充S. boulardii mafic-1701增加了Ruminococcaceae_UCG_009和Turicibacter的丰度（P <0.05），而unclassified_Clostridiaceae_4的丰度降低了（P <0.05）。此外，S。boulardii mafic-1701的使用增加了盲肠微生物代谢产物，异丁酸酯和戊酸酯的盲肠浓度（P <0.05）。饲料转化率的提高，