A real-time RF exposure setup for studying the mechanism of RF biological effects based on microelectrode array (MEA) is proposed in this letter. The reflection simulation and measurement of the exposure setup show that the exposure setup has a wide working bandwidth in the frequency range of dc-3.0 GHz. The specific adsorption rate (SAR) measurement and simulation results at some frequencies show that the SAR distributions in the electrode region are relatively uniform. The test of the real-time effects on neuron activities at the SAR of 2.2 W/kg with a continuous 2.45-GHz RF signal injection was carried out. The results show that most of the electrodes can work normally and will not be affected by electromagnetic field noise. Additionally, the setup is compact and the system with MEA platform is almost covered by metal, which would significantly improve the ability to isolate the internal and external electromagnetic waves.

中文翻译：

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基于微电极阵列的紧凑型宽带宽实时射频曝光设置

这封信中提出了一种用于研究基于微电极阵列 (MEA) 的射频生物效应机制的实时射频暴露设置。曝光装置的反射模拟和测量表明，曝光装置在 dc-3.0 GHz 的频率范围内具有较宽的工作带宽。某些频率下的比吸附率 (SAR) 测量和模拟结果表明，电极区域的 SAR 分布相对均匀。在 2.2 W/kg 的 SAR 和连续 2.45 GHz 射频信号注入下对神经元活动的实时影响进行了测试。结果表明，大部分电极都能正常工作，不会受到电磁场噪声的影响。此外，设置紧凑，带有 MEA 平台的系统几乎被金属覆盖，