Increasing data support that herbal medicines are beneficial in the treatment of cervical cancer; however, their mechanisms of action remain to be elucidated. In the current study, we used a systems pharmacology approach to explore the pharmacological mechanisms of FDY003, an anticancer herbal formula comprising Lonicera japonica Thunberg, Artemisia capillaris Thunberg, and Cordyceps militaris (Linn.) Link, in the treatment of cervical cancer. Through the pharmacokinetic assessment of absorption-distribution-metabolism-excretion characteristics, we found 18 active compounds that might interact with 106 cervical cancer-related targets responsible for the pharmacological effects. FDY003 targets were significantly associated with gene ontology terms related to the regulation of cellular behaviors, including cell proliferation, cell cycle processes, cell migration, cell apoptosis, cell death, and angiogenesis. The therapeutic targets of the herbal drug were further enriched in various oncogenic pathways that are implicated in the tumorigenesis and progression of cervical cancer, including the phosphatidylinositol 3-kinase, mitogen-activated protein kinase, focal adhesion, human papillomavirus infection, and tumor necrosis factor signaling pathways. Our study provides a systematic approach to explore the anticancer properties of herbal medicines against cervical cancer.

越来越多的数据支持草药对宫颈癌的治疗有益；但是，它们的作用机理还有待阐明。在目前的研究中，我们使用一个系统药理学方法来探索FDY003的药理学机制，包括抗癌草药配方忍冬瓢虫，茵陈瓢虫，和蛹虫草（Linn。）Link，用于治疗宫颈癌。通过吸收，分布，代谢和排泄特征的药代动力学评估，我们发现了18种可能与106种与宫颈癌相关的靶标相互作用的药理学相互作用的活性化合物。FDY003靶标与与细胞行为调节相关的基因本体术语显着相关，包括细胞增殖，细胞周期过程，细胞迁移，细胞凋亡，细胞死亡和血管生成。草药的治疗目标进一步丰富了与宫颈癌的发生和发展有关的各种致癌途径，包括磷脂酰肌醇3激酶，促分裂原活化蛋白激酶，粘着斑，人乳头瘤病毒感染，和肿瘤坏死因子信号通路。我们的研究提供了系统的方法来探索草药对宫颈癌的抗癌特性。