Regulation of membrane proteins through local heterogeneity in lipid bilayer thickness,Physical Review E

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Regulation of membrane proteins through local heterogeneity in lipid bilayer thickness
Physical Review E ( IF 2.2 ) Pub Date : 2020-12-04 , DOI: 10.1103/physreve.102.060401
Ahis Shrestha ₁ , Osman Kahraman ₁ , Christoph A Haselwandter ₁

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Cell membranes show an intricate organization of lipids and membrane proteins into domains with distinct composition and hydrophobic thickness. Using mechanosensitive ion channels as a model system, we employ the membrane elasticity theory of lipid-protein interactions together with the Landau-Ginzburg theory of lipid domain formation to quantify protein-induced lipid bilayer thickness deformations in lipid bilayers with heterogeneous hydrophobic thickness. We show that protein-induced lipid bilayer thickness deformations yield, without any assumptions about preferential interactions between particular lipid and protein species, organization of lipids and membrane proteins according to their preferred hydrophobic thickness, and couple the conformational states of membrane proteins to the local membrane composition. Our calculations suggest that protein-induced lipid bilayer thickness deformations endow proteins in cell membranes with diverse and controlled mechanical environments that, in turn, allow targeted regulation of membrane proteins.

中文翻译：

通过脂质双层厚度的局部异质性调节膜蛋白

细胞膜显示出脂质和膜蛋白复杂的组织结构，形成具有不同组成和疏水厚度的结构域。使用机械敏感离子通道作为模型系统，我们采用脂质-蛋白质相互作用的膜弹性理论以及脂质结构域形成的Landau-Ginzburg理论来量化具有异质疏水厚度的脂质双层中蛋白质诱导的脂质双层厚度变形。我们表明，蛋白质诱导的脂质双层厚度变形产生，无需任何关于特定脂质和蛋白质种类之间的优先相互作用的假设，根据脂质和膜蛋白的首选疏水厚度组织脂质和膜蛋白，并将膜蛋白的构象状态与局部膜耦合作品。我们的计算表明，蛋白质诱导的脂质双层厚度变形赋予细胞膜中的蛋白质多样化且受控的机械环境，从而允许对膜蛋白进行靶向调节。

更新日期：2020-12-04

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