Abstract

A green, efficient and convenient synthesis of pyrano[2,3-d]pyrimidine scaffolds has been developed via one-pot three-component reaction of aryl aldehyde derivatives, malononitrile with barbituric acid/1,3-dimethylbarbituric acid using ethylene glycol (E-G) as a solvent as well as catalyst. Eighteen pyrano[2,3-d]pyrimidine scaffolds were selected for the library validation. The superiority of this method is environmental safety, catalyst-free, operational simplicity, metal-free, high yields, excellent functional group tolerance, easy workup procedure, less reaction time and the green ethylene glycol can be recovered and reused several times without any loss of efficiency.

中文翻译：

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乙二醇 (EG) 中作为可回收反应介质的吡喃并[2,3-d]嘧啶支架的无催化剂三组分串联绿色合成

摘要

通过芳基醛衍生物丙二腈与巴比妥酸/ 1,3-二甲基巴比妥酸与乙二醇 (EG ) 作为溶剂和催化剂。选择了十八个吡喃并[2,3- d ]嘧啶支架用于文库验证。该方法的优点是环境安全、无催化剂、操作简单、无金属、收率高、官能团耐受性好、后处理简单、反应时间短、绿色乙二醇可多次回收重复利用而无任何损失的效率。