ABSTRACT

Introduction: Drug eluting implants offer patient convenience and improved compliance through less frequent dosing, eliminating repeated, painful injections and providing localized, site specific delivery with applications in contraception, ophthalmology, and oncology.

Areas covered: This review provides an overview of available implant products, design approaches, biodegradable and non-biodegradable polymeric materials, and fabrication techniques with a focus on commercial applications and industrial drug product development. Developing trends in the field, including expanded availability of suitable excipients, development of novel materials, scaled down manufacturing process, and a wider understanding of the implant development process are discussed and point to opportunities for differentiated drug eluting implant products.

Expert opinion: In the future, long-acting implants will be important clinical tools for prophylaxis and treatment of global health challenges, especially for infectious diseases, to reduce the cost and difficulty of treating chronic indications, and to prolong local delivery in difficult to administer parts of the body. These products will help improve patient safety, adherence, and comfort.

摘要

简介: 药物洗脱植入物通过减少给药频率、消除重复、痛苦的注射以及提供局部、特定部位递送以及避孕、眼科和肿瘤学方面的应用，为患者提供便利并提高依从性。

涵盖的领域：本综述概述了可用的植入产品、设计方法、可生物降解和不可生物降解的聚合物材料以及制造技术，重点是商业应用和工业药品开发。讨论了该领域的发展趋势，包括适当赋形剂的扩大可用性、新材料的开发、缩小制造过程以及对植入物开发过程的更广泛理解，并指出了差异化药物洗脱植入物产品的机会。

专家意见：未来，长效植入物将成为预防和治疗全球健康挑战，尤其是传染病的重要临床工具，以降低慢性适应症的治疗成本和难度，并在难以管理的情况下延长局部分娩时间身体的一部分。这些产品将有助于提高患者的安全性、依从性和舒适度。