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Thymectomy and myasthenia gravis [Immunology and Inflammation]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-12-22 , DOI: 10.1073/pnas.2022901117
Robert P. Lisak 1, 2 , David P. Richman 3, 4
Affiliation  

Myasthenia gravis (MG) is a disorder of the neuromuscular junction mediated by the actions of autoantibodies directed against one of several proteins expressed on the postjunction muscle membrane. For the large majority of MG patients the target for the autoantibodies is the acetylcholine receptor (AChR) (1) that interacts with acetylcholine, the transmitter released by the motor nerve, to trigger muscle contraction.

中文翻译:

胸腺切除术和重症肌无力[免疫学和炎症]

重症肌无力(MG)是由针对结后肌膜表达的几种蛋白质之一的自身抗体介导的神经肌肉接头疾病。对于大多数MG患者,自身抗体的靶标是乙酰胆碱受体(AChR)(1),它与乙酰胆碱(由运动神经释放的递质)相互作用,触发肌肉收缩。
更新日期:2020-12-24
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