Fluorescent semiconductor nanoparticles or quantum dots (QDs) have excellent properties as photosensitizers in photodynamic therapy. This is mainly a consequence of their nanometric size and the generation of light-activated redox species. In previous works, we have reported the low-cost biomimetic synthesis of glutathione (GSH) capped QDs (CdTe-GSH QDs) with high biocompatibility. However, no studies have been performed to determine their phototoxic effect. The aim of this work was to characterize the light-induced toxicity of green (QDs₅₀₀) and red (QDs₆₀₀) QDs in Escherichia coli, and to study the molecular mechanism involved.

中文翻译：

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仿生CdTe-GSH量子点的细菌光毒性

荧光半导体纳米粒子或量子点 (QD) 作为光动力疗法中的光敏剂具有优异的特性。这主要是由于它们的纳米尺寸和光活化氧化还原物质的产生。在以前的工作中，我们报道了具有高生物相容性的谷胱甘肽（GSH）加帽量子点（CdTe-GSH QDs）的低成本仿生合成。然而，尚未进行任何研究来确定它们的光毒性作用。这项工作的目的是表征绿色 (QDs ₅₀₀ ) 和红色 (QDs ₆₀₀ ) 量子点在大肠杆菌中的光诱导毒性，并研究所涉及的分子机制。