A 3-day-old Australian Stock Horse filly presented with fulminant acute kidney injury after receiving 4 g of intravenous oxytetracycline at 24 and 48 h of age for medical management of flexural deformities. The filly’s clinical status initially improved, but worsening azotaemia prompted euthanasia after 55 h of supportive care. Necropsy confirmed proximal tubular necrosis. Nephropathy in association with oxytetracycline administration has been rarely reported. This case describes severe nephropathy in an apparently normal foal and highlights the need for thorough case evaluation prior to use of high-dose oxytetracycline therapy for correction of flexural deformities in foals.

中文翻译：

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土霉素相关的新生儿小马急性肾损伤

一头 3 日龄的澳大利亚种马小马在 24 和 48 小时接受 4 g 静脉注射土霉素治疗弯曲畸形后出现暴发性急性肾损伤。母马的临床状况最初有所改善，但在支持性护理 55 小时后，氮质血症的恶化促使安乐死。尸检证实近端肾小管坏死。与土霉素给药相关的肾病鲜有报道。该病例描述了明显正常的小马驹的严重肾病，并强调了在使用大剂量土霉素治疗矫正小马驹弯曲畸形之前对病例进行彻底评估的必要性。