Body surface mapping of the stomach: New directions for clinically evaluating gastric electrical activity,Neurogastroenterology & Motility

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Body surface mapping of the stomach: New directions for clinically evaluating gastric electrical activity
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-12-04 , DOI: 10.1111/nmo.14048
Daniel A Carson ₁ , Greg O'Grady _{1,

2} , Peng Du _{2,

3} , Armen A Gharibans _{1,

2} , Christopher N Andrews ₄

Affiliation

Gastric motility disorders, which include both functional and organic etiologies, are highly prevalent. However, there remains a critical lack of objective biomarkers to guide efficient diagnostics and personalized therapies. Bioelectrical activity plays a fundamental role in coordinating gastric function and has been investigated as a contributing mechanism to gastric dysmotility and sensory dysfunction for a century. However, conventional electrogastrography (EGG) has not achieved common clinical adoption due to its perceived limited diagnostic capability and inability to impact clinical care. The last decade has seen the emergence of novel high‐resolution methods for invasively mapping human gastric electrical activity in health and disease, providing important new insights into gastric physiology. The limitations of EGG have also now become clearer, including the finding that slow‐wave frequency alone is not a reliable discriminator of gastric dysrhythmia, shifting focus instead toward altered spatial patterns. Recently, advances in bioinstrumentation, signal processing, and computational modeling have aligned to allow non‐invasive body surface mapping of the stomach to detect spatiotemporal gastric dysrhythmias. The clinical relevance of this emerging strategy to improve diagnostics now awaits determination.

中文翻译：

胃体表映射：临床评估胃电活动的新方向

包括功能性和器质性病因的胃动力障碍非常普遍。然而，仍然严重缺乏客观的生物标志物来指导有效的诊断和个性化治疗。生物电活动在协调胃功能方面发挥着重要作用，并且一个世纪以来一直被研究为胃动力障碍和感觉功能障碍的促成机制。然而，传统的胃电图（EGG）由于其诊断能力有限且无法影响临床护理，尚未实现普遍的临床应用。在过去的十年中，出现了新的高分辨率方法，用于对健康和疾病中的人体胃电活动进行侵入性绘图，为胃生理学提供了重要的新见解。EGG 的局限性现在也变得更加清晰，包括发现仅慢波频率并不是胃节律失常的可靠鉴别器，而是将注意力转移到改变的空间模式上。最近，生物仪器、信号处理和计算建模方面的进展已使胃部的非侵入性体表映射能够检测时空胃节律失常。这种改进诊断的新兴策略的临床相关性现在有待确定。和计算模型已经对齐，允许胃的非侵入性体表映射来检测时空胃节律失常。这种改进诊断的新兴策略的临床相关性现在有待确定。和计算模型已经对齐，允许胃的非侵入性体表映射来检测时空胃节律失常。这种改进诊断的新兴策略的临床相关性现在有待确定。

更新日期：2020-12-04

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