Leveraging a phenome‐wide approach to identify novel exposure‐birth defect associations: A proof of concept using maternal smoking and a spectrum of birth defects,Birth Defects Research

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Leveraging a phenome‐wide approach to identify novel exposure‐birth defect associations: A proof of concept using maternal smoking and a spectrum of birth defects
Birth Defects Research ( IF 1.6 ) Pub Date : 2020-12-04 , DOI: 10.1002/bdr2.1851
Peter H Langlois ₁ , Jeremy M Schraw _{2,

3,

4} , Adrienne T Hoyt ₅ , Philip J Lupo _{2,

3,

4}

Affiliation

There are often questions about the impact of exposures on a range of birth defects, but there are few rigorous approaches for evaluating these associations. Using maternal smoking as an example we applied a phenome‐wide association study (PheWAS) approach to evaluate the impact of this exposure on a comprehensive range of birth defects.

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