Objective

To assess the agreement between an oscillometric device and invasive blood pressure (IBP) measurements in anesthetized healthy adult guinea pigs.

Study design

Prospective experimental study.

Animals

A total of eight adult Hartley guinea pigs.

Methods

All animals were anesthetized; a carotid artery was surgically exposed and catheterized for IBP measurements. A size 1 cuff placed on the right thoracic limb was connected to an oscillometric device for noninvasive blood pressure (NIBP) assessment. Concurrent pairs of systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressures were recorded simultaneously with both methods every 3 minutes for 30 minutes. Agreement between IBP and NIBP measurements was determined using the Bland–Altman method, considering the recommended standards for the validation of NIBP measurement devices proposed by the American College of Veterinary Internal Medicine (ACVIM).

Results

The bias and the 95% limits of agreement were: –14 (–31 to 3) mmHg, –2 (–14 to 10) mmHg and –1 (–13 to 11) mmHg for SAP, DAP and MAP, respectively.

Conclusions and clinical relevance

The oscillometric device used in this study to measure NIBP did not meet ACVIM criteria for validation. It showed good agreement for DAP and MAP but not for SAP measurements. Considering the small size of these animals and the resulting difficulty in performing percutaneous arterial catheterization, this device might be a useful tool to assess MAP and DAP during anesthetic procedures in adult guinea pigs.

中文翻译：

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异氟醚麻醉豚鼠 (Cavia porcellus) 无创示波和有创血压测量之间的一致性

客观的

评估示波装置与麻醉健康成年豚鼠的有创血压 (IBP) 测量值之间的一致性。

学习规划

前瞻性实验研究。

动物

总共八只成年哈特利豚鼠。

方法

所有动物都被麻醉；通过手术暴露颈动脉并插入导管进行 IBP 测量。放置在右胸肢上的 1 号袖带连接到用于无创血压 (NIBP) 评估的示波装置。使用两种方法同时记录收缩压 (SAP)、舒张压 (DAP) 和平均 (MAP) 动脉压的同时对，每 3 分钟一次，持续 30 分钟。考虑到美国兽医内科学会 (ACVIM) 提出的用于验证 NIBP 测量设备的推荐标准，使用 Bland-Altman 方法确定 IBP 和 NIBP 测量值之间的一致性。

结果

SAP、DAP 和 MAP 的偏差和 95% 的一致性限制分别为：–14（–31 到 3）mmHg、–2（–14 到 10）mmHg 和 –1（–13 到 11）mmHg。

结论和临床相关性

本研究中用于测量 NIBP 的示波装置不符合 ACVIM 验证标准。它显示了 DAP 和 MAP 的良好一致性，但不适用于 SAP 测量。考虑到这些动物的体型较小，并且因此难以进行经皮动脉导管插入术，该装置可能是评估成年豚鼠麻醉过程中 MAP 和 DAP 的有用工具。