Photobiomodulation (PBM) is reported to impart a range of clinical benefits, from the healing of chronic wounds to athletic performance enhancement. The increasing prevalence of this therapy conflicts with the lack of understanding concerning specific cellular mechanisms induced by PBM. Herein, we systematically explore the literature base, specifically related to PBM (within the range 600-1070 nm) and its influence on dermal fibroblasts. The existing research in this field is appraised through five areas: cellular proliferation and viability; cellular migration; ATP production and mitochondrial membrane potential; cellular protein expression and synthesis; and gene expression. This review demonstrates that when fibroblasts are irradiated in vitro within a set range of intensities, they exhibit a multitude of positive effects related to the wound healing process. However, the development of an optimal in vitro framework is paramount to improve the reliability and validity of research in this field.

据报道，光生物调节（PBM）可带来一系列的临床益处，从慢性伤口的愈合到运动成绩的提高。这种疗法的流行与缺乏对由PBM诱导的特定细胞机制的理解相冲突。在本文中，我们系统地探讨了与PBM（在600-1070 nm范围内）及其对皮肤成纤维细胞的影响特别相关的文献基础。该领域的现有研究通过五个领域进行评估：细胞增殖和生存力；细胞迁移；ATP产生和线粒体膜电位；细胞蛋白表达与合成；和基因表达。这项审查表明，当体外照射成纤维细胞时在一定强度范围内，它们表现出与伤口愈合过程有关的多种积极作用。但是，开发最佳体外框架对于提高该领域研究的可靠性和有效性至关重要。