Purpose

To test the Contact Lens Assessment in Youth Contact Lens Risk Survey (CLRS) scoring algorithm in soft contact lens (SCL) wearers presenting with SCL-related adverse events and healthy matched controls.

Methods

This prospective case-control study compared CLRS responses in SCL wearers presenting with symptomatic red eyes (Cases) with age-, sex- and site-matched healthy SCL wearers (Controls) at six locations across North America. Responses to individual questions from Cases and Controls were analyzed using either the Pearson, Mantel-Haenszel chi-square, or Fisher’s exact test. Differences in the CLRS scores were compared using t-tests.

Results

A total of 171 SCL wearers were enrolled (n = 57 Cases, 114 Controls). Cases were adjudicated to consensus and classified as contact lens-related serious and significant (S&S) or non-serious events. S&S Cases scored significantly higher on the CLRS (56.1 ± 11.1) than either their matched Controls (44.3 ± 11.1) (P < 0.001) or the non-Serious Cases (44.8± 12.8 P = 0.002). Scores of non-serious Cases were not significantly different than scores of their Controls (43.4 ± 10.7, P = 0.33)

Conclusions

The CLRS scoring algorithm discriminated between SCL wearers presenting with S&S CL-related adverse events from healthy SCL wearers and those with non-serious events. This survey and scoring system could help practitioners identify patients at greatest risk for CL-related adverse events and support targeted interventions aimed at reducing risk behaviors.

中文翻译：

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用于评估软性隐形眼镜相关炎症事件风险的隐形眼镜风险调查

目的

在出现 SCL 相关不良事件和健康匹配对照的软性隐形眼镜 (SCL) 佩戴者中测试青年隐形眼镜风险调查 (CLRS) 评分算法中的隐形眼镜评估。

方法

这项前瞻性病例对照研究比较了在北美六个地点出现症状性红眼的 SCL 佩戴者（病例）与年龄、性别和部位匹配的健康 SCL 佩戴者（对照组）的 CLRS 反应。使用 Pearson、Mantel-Haenszel 卡方或 Fisher 精确检验分析案例和对照对个别问题的回答。使用 t 检验比较 CLRS 分数的差异。

结果

共招募了 171 名 SCL 佩戴者（n = 57 个病例，114 个对照）。案例被裁定为共识，并归类为与隐形眼镜相关的严重和重大 (S&S) 或非严重事件。S&S 病例在 CLRS (56.1 ± 11.1) 上的得分明显高于其匹配的对照 (44.3 ± 11.1) ( P  < 0.001) 或非严重病例 (44.8 ± 12.8 P  = 0.002)。非严重病例的分数与其对照组的分数没有显着差异 (43.4 ± 10.7, P = 0.33)

结论

CLRS 评分算法区分出现 S&S CL 相关不良事件的 SCL 佩戴者与健康 SCL 佩戴者和非严重事件的佩戴者。该调查和评分系统可以帮助从业者识别 CL 相关不良事件风险最大的患者，并支持旨在减少风险行为的有针对性的干预措施。