Sugarcane vinasse, also known as distillery wastewater, is a key by-product of the ethanol industry. Vinasse characteristics and their huge volume pose environmental concerns about the choice of treatment method. Microfiltration (MF) has been efficiently applied to vinasse clarification; however, it has been underexplored in the literature. In this context, the present study investigated the application of coagulation and cross-flow MF for vinasse clarification. To maximize the process efficiency, operational parameters were optimized using the one-factor-at-a-time method in batch tests. The optimal values were Superfloc C492 concentration of 5 mg L⁻¹, backpulsing frequency of 10 min, and vinasse temperature of 45 °C, which showed a removal of 35.0, 86.0, and 99.9% for chemical oxygen demand (COD), color, and turbidity, respectively. The optimization process significantly improved the vinasse flux but did not show any influence in the permeate quality. Optimal parameters were successfully applied to the continuous mode in the MF system, which operated during 164 h at an average flux of 21.6 L h⁻¹ m⁻². High removals were reached for color (79.3%) and turbidity (99.6%), and low removal was found for COD (31.6%), which are in agreement with the batch mode tests. This work showed the importance of operational optimization, and the results provide valuable support for establishing practical guidelines for vinasse clarification in the ethanol industry.

甘蔗酒糟，也被称为酒厂废水，是乙醇工业的重要副产品。酒糟特性及其巨大的体积对选择处理方法提出了环境方面的关注。微滤（MF）已有效地用于酒糟的澄清；但是，它在文献中还没有得到充分的研究。在这种情况下，本研究调查了混凝和错流MF在酒糟澄清中的应用。为了使过程效率最大化，在批处理测试中使用一次一因素法优化了操作参数。最佳值为Superfloc C492浓度为5 mg L ^-1，10分钟的反脉冲频率和45°C的酒糟温度，分别显示化学需氧量（COD），颜色和浊度的去除率为35.0％，86.0和99.9％。优化过程显着改善了酒糟通量，但对渗透质量没有任何影响。最佳参数已成功应用于MF系统的连续模式，该模式在164小时内以21.6 L h ^-1  m ^-2的平均通量运行。颜色（79.3％）和浊度（99.6％）的去除率高，而COD（31.6％）的去除率低，这与分批模式测试一致。这项工作表明了操作优化​​的重要性，其结果为建立乙醇工业中澄清酒糟的实用指南提供了宝贵的支持。