The protolytic properties and reactions with molecular iodine and blood serum proteins of 5,7-dimethyltetrahydro-1H-imidazo[4,5-e]-1,2,4-triazine-3,6(2H,4H)-dithione and (R)-1,3-dialkyl-4-[(2-hydroxybenzylidene)amino]-5-thioxohexahydroimidazo[4,5-d]imidazol-2(1H)-ones were studied. These compounds exhibit different chemical reactivities towards molecular iodine. The binding constants between these compounds and serum albumin attest to a considerable protein affinity of the compounds. The properties of the thiones make them promising as antithyroid agents.

中文翻译：

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巯基脲和稠合的 azolo-1,2,4-triazines 的质子分解和潜在的抗甲状腺特性

5,7-二甲基四氢-1H-咪唑并[4,5-e]-1,2,4-三嗪-3,6(2H,4H)-二硫酮和(研究了 R)-1,3-二烷基-4-[(2-羟基苯亚甲基) 氨基]-5-thioxohexahydroimidazo[4,5-d]imidazol-2(1H)-ones。这些化合物对分子碘表现出不同的化学反应性。这些化合物与血清白蛋白之间的结合常数证明了这些化合物具有相当大的蛋白质亲和力。硫酮的特性使它们有希望作为抗甲状腺药物。