Magnetic nanobeads can be applied to the magnetic separation of nucleic acids which can be used for diagnosing infectious and genetic diseases of patients. In this study, core-shell structured silica-coated iron oxide (Fe₃O₄@SiO₂) nanobeads with a core size distribution of 40–50 nm and a shell thickness of ∼ 10 nm were synthesized and applied to the magnetic separation of nucleic acids from various biological samples such as cancer cells, viruses, and bacteria. The iron oxide core provided strong superparamagnetic properties with a high saturation magnetization suitable for magnetic separation, and the silica shell provided binding surfaces for nucleic acids. The Fe₃O₄@SiO₂ nanobeads showed the successful magnetic separation performance for all samples.

磁性纳米珠可用于核酸的磁性分离，可用于诊断患者的传染性和遗传性疾病。在这项研究中，合成了核-壳结构的二氧化硅包覆的氧化铁（Fe ₃ O ₄ @SiO ₂）纳米珠，其核尺寸分布为40–50 nm，壳厚度约为10 nm，并将其用于磁选。来自各种生物样品（例如癌细胞，病毒和细菌）的核酸。氧化铁核提供了强大的超顺磁性，并具有适合磁分离的高饱和磁化强度，而二氧化硅壳提供了核酸的结合表面。Fe ₃ O ₄ @SiO ₂ 纳米珠对所有样品均显示出成功的磁分离性能。